Which of the following is a responsibility of GPC cardholders?

B is the correct answer because one of the core responsibilities of Government Purchase Card (GPC) cardholders is to ensure compliance with all applicable regulations and policies related to the use of the purchase card program. This includes understanding the permissible uses of the card, adhering to spending limits, and following proper procurement procedures. Additionally, documentation must be retained for all purchases made with the GPC to provide evidence of compliance for audits and reviews, which is vital for maintaining accountability and transparency within government spending.

The remaining options do not accurately reflect the responsibilities of GPC cardholders. For example, approving all government purchases for any agency far exceeds the authority granted to individual cardholders, who are limited to purchases specific to their own responsibility. Managing the agency's entire budget also falls outside the scope of a GPC cardholder’s role, as this is typically a responsibility assigned to budget officers or financial managers. Likewise, authorizing contractors to make purchases is not within the purview of GPC cardholders, who are primarily responsible for their own transactions rather than managing contractor procurement activities.